Effect of histamine receptor antagonists on bile damage to the gastric mucosa of canine Heidenhain pouches.
نویسندگان
چکیده
The net ionic fluxes of H+ and Na+ were examined in Heidenhain pouches during damage with sodium taurocholate solution. The increase in ionic flux which occurred with taurocholate could be prevented in animals given H1 and H2 histamine antagonists in combination. The results suggest that histamine mediates changes in the transmucosal ionic flux produced by bile acid.
منابع مشابه
Inhibitory action of cholecystokinin on acid secretion from Heidenhain pouches induced by endogenous gastrin.
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متن کاملBile salt-induced gastric mucosal damage and histamine
The effects of both an H1 receptor antagonist and an H2 receptor antagonist on changes in monovalent ion flux induced by topical sodium taurocholate were studied in antrectomised dogs fashioned with a denervated fundic pouch. The magnitude of taurocholateinduced ion flux was unaffected by topical administration of H1 or H2 receptor antagonists. Parenteral administration of H1 or H2 receptor ant...
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ورودعنوان ژورنال:
- Gut
دوره 18 10 شماره
صفحات -
تاریخ انتشار 1977