Pancuronium bromide, 1,1 -(3a ,17b-diacetoxy-5a-andro- stan-2b ,16b-ylene)bis(1-methyl-piperidinium) dibromide [15500-66-0] is general anaesthesia used in surgery for mus- cle relaxation and as an aid to endotracheal intubation
ثبت نشده
چکیده
stan-2b ,16b-ylene)bis(1-methyl-piperidinium) dibromide [15500-66-0] is general anaesthesia used in surgery for muscle relaxation and as an aid to endotracheal intubation (Chart 1). Several methods of determination of this drug have been reported in the literature, including high performance liquid chromatography (HPLC), capillary gas chromatography using nitrogen sensitive detection, liquid chromatography-mass spectrometry spectrophotometric, fluorimetric, and mass spectrometric, methods. A potentiometric ion selective electrode method based on pancuronium-tetraphenylborate and pancuronium-dipicrylaminate has been reported. The aim of this study is to describe the construction, performance characteristics of pancuronium modified carbon paste electrodes based on the pancuronium-tetraphenylborate (Panc-TPB) and pancuronium-reineckate as electroactive material and dibutyl phthalate as solvent mediator and the analytical applications of these sensors in determination of pancuronium bromide in pharmaceutical preparation and biological fluids in batch and flow injection conditions.
منابع مشابه
بررسی و مقایسه تأثیر آتراکوریوم و پانکرونیوم بر روی فشار داخل کره چشم در اعمال جراحی کاتاراکت
Introduction: Cataract is an opacified lens and senile cataract is a common disorder. It is desirable to reduce intraocular pressure (IOP) in order to minimize intra and post operative difficulties and complications. Many researches have studied the effects of muscle relaxants on IOP. Comparison effect of atracurium and pancuronium on IOP has been evaluated in one study with a small sample size...
متن کاملChanges in respiratory mechanics during extraperitoneal insufflation in inguinal hernia surgery
Anaesthesia was induced with midazolam 1 mg, fentanyl 2 μg/kg and propofol 2 mg/kg intravenously. Vecuronium bromide 0.1 mg/kg intravenously was used for muscle relaxation followed by endotracheal intubation. Anaesthesia was maintained with 1-2% sevoflurane in 50% O2 and N2O gas mixture. Intraoperative analgesia was provided with incremental doses of intravenous fentanyl 1 μg/kg and muscle rela...
متن کاملThe LMACTrach, a new approach for endotracheal intubation: Apilot study in 100 patients undergoing elective surgery
AbstractBackgroundand endotracheal intubation under direct vision in both anticipated and unexpecteddifficult intubation situations.: The LMA CTrach system is a new device for airway managementMethodsdifferent types of elective surgeries. After randomly selecting the patients for intubationwith this new device, the airway characteristics, height, weight, dental overbiteand thyromental distance ...
متن کاملEvaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia
Background &Objective: Plaryngoscopy and tracheal intubation increase not only blood pressure and heart rate but also Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and during general anesthesia followed by mexiletine prescription . Materials & Methods: In this study, 50 patients aged between 20 and 60 who were ca...
متن کاملPostoperative muscle pains and suxamethonium.
Two matched groups of patients with Hodgkin's disease undergoing a staging laparotomy received thiopentone, pancuronium bromide or suxamethonium 1.0 mg kg-1 (group 2) to facilitate tracheal intubation. There were no differences in the sites or degree of postoperative myalgia between the groups. It is concluded that efforts to reduce the frequency of suxamethonium muscle pains in patients having...
متن کامل