Synthesis, characterization and biological activities of substituted cinnoline culphonamides.
نویسندگان
چکیده
BACKGROUND The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties. METHODS In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity. RESULTS These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity. CONCLUSION Further investigations are required to find out possible mechanism of action.
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ورودعنوان ژورنال:
- African health sciences
دوره 9 4 شماره
صفحات -
تاریخ انتشار 2009