Synthesis, characterization and biological activities of substituted cinnoline culphonamides.

نویسندگان

  • Saxena Vikas
  • S Darbhamulla
چکیده

BACKGROUND The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties. METHODS In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity. RESULTS These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity. CONCLUSION Further investigations are required to find out possible mechanism of action.

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عنوان ژورنال:
  • African health sciences

دوره 9 4  شماره 

صفحات  -

تاریخ انتشار 2009