PVT1: A Cancer-associated Non-coding Gene Revisited

PVT1 was originally identified as a transcriptional unit from a human homologous sequence to Pvt1, which was cloned from murine plasmacytoma with t(6;15). Previous studies have revealed various genetic alterations in the PVT1 locus, including chromosome translocation, amplification, chromothripsis, and single nucleotide polymorphisms in human diseases, suggesting important roles of PVT1 in the pathogenesis. However, because this locus does not produce protein coding sequences, its functional properties have not been characterized and its biological significance remains unclear. Recent studies have shown that the PVT1 locus encodes lincRNAs and microRNAs. Therefore, current investigations are being performed focusing on the biological features of this long-standing puzzle gene as a non-coding gene. *Corresponding author: Takashi Sonoki, Hematology/Oncology, Wakayama Medical University, 811-1 Kimi-idera, Wakayama, 641-8510, Japan, Tel: +81-73441-0665; Fax: +81-73-441-0653; E-mail: [email protected] Received August 24, 2013; Accepted January 15, 2014; Published January 17, 2014 Citation: Sonoki T (2014) PVT1: A Cancer-associated Non-coding Gene Revisited. Clon Transgen 3: 120. doi:10.4172/2168-9849.1000120 Copyright: © 2014 Sonoki T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.