Multiscale Modeling of Blast Induced Traumatic Brain Injury: from Whole Body Responses to Brain Microdamage
نویسندگان
چکیده
The blast induced traumatic brain injury (bTBI) has become a signature wound of the war on terror 1 . The majority of combat related TBI cases are categorized as mild (mTBI) based on the event history and cognitive symptoms such as: concentration problems, blurred vision, irritability, headaches, sleep disorders and depression 2 . In spite of immense clinical and preclinical research on TBI current understanding of injury mechanisms is limited, diagnostics and treatment remain controversial and little is known about the shortand longterm outcomes of mTBI. Compared to impact-related brain injury, the mechanisms involved in blast induced mTBI are much less understood. Mathematical models of human body, head and brain responses to a blast wave may provide a capability to study brain injury mechanisms, perhaps accelerating the development of neuroprotective strategies and aiding in the development of improved protective armor 1 .
منابع مشابه
Biomechanical analysis of blast-induced traumatic brain injury
Purpose: Blast-induced traumatic brain injury (bTBI) is one of the causes of death or permanent invalidity which can occur unexpectedly in both military and civilian populations. This study set out to conduct a combined Eulerian-Lagrangian computational analysis of the interaction between a single planar blast wave and a human head in order to assess the extent of intracranial shock w...
متن کاملMultiscale Modelling of Blast-Induced TBI Mechanobiology - From Body to Neuron to Molecule
Blast induced traumatic brain injury (bTBI) has become a signature wound of the recent military operations and is becoming a significant factor of recent civilian blast explosion events. In spite of significant clinical and preclinical research on TBI, current understanding of injury mechanisms is limited and little is known about the short-term and long-term outcomes. Mathematical models of bT...
متن کاملA patient with a traumatic brain injury due to barrel bomb tertiary blast effect
Preparing to manage weapons of mass destruction events challenges emergency services systems neighboring Syria every day. Understanding injury from explosives is essential for all providers of emergency care in both civilian and military settings. In this case, the authors present a 22-year-old man who was admitted to the emergency department with displaced skull fracture, epidural hemorrhage ...
متن کاملMathematical Models of Blast-Induced TBI: Current Status, Challenges, and Prospects
Blast-induced traumatic brain injury (TBI) has become a signature wound of recent military activities and is the leading cause of death and long-term disability among U.S. soldiers. The current limited understanding of brain injury mechanisms impedes the development of protection, diagnostic, and treatment strategies. We believe mathematical models of blast wave brain injury biomechanics and ne...
متن کاملThe Effects of Estrogen Receptors' Antagonist on Brain Edema, Intracranial Pressure and Neurological Outcomes after Traumatic Brain Injury in Rat
Background: In previous studies, the neuroprotective effect of 17&beta-estradiol in diffuse traumatic brain injury has been shown. This study used ICI 182,780, a non-selective estrogen receptor antagonist, to test the hypothesis that the neuroprotective effect of 17&beta-estradiol in traumatic brain injury is mediated by the estrogen receptors. Methods: The ovariectomized rats were divided into...
متن کامل