A Study of Selenate Placental Microvillus
نویسنده
چکیده
Selenate efflux from human placental brush border membrane vesicles was studied using an ion-exchange column assay. Selenate efflux was found to be mediated almost exclusively by a temperature dependent DIDS-sensitive pathway. Chromate markedly inhibited selenate efflux: in contrast medium selenate had no effect. It is concluded that selenate and sulphate share a common pathway for transport across the human placental microvillus membrane.
منابع مشابه
Selenium (selenate) transport by human placental brush border membrane vesicles
Selenium is an essential trace element required by the fetus for normal growth, therefore knowledge on the placental transport of Se is important in the context of fetal nutrition. Recent work in this laboratory has shown that selenate is a competitive inhibitor of sulphate uptake by vesicles prepared from the brush-border membrane of the syncytiotrophoblast of the human term placenta (Shennan ...
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