An Expedient Total Synthesis of Triciribine.
نویسندگان
چکیده
In the present paper, we report an expedient total synthesis of triciribine, a tricyclic 7-deazapurine nucleoside and protein kinase B (AKT ) inhibitor, in 35% overall yield. Our synthesis route features a highly regioselective substitution of 1-N-Boc-2-methylhydrazine and a trifluoroacetic acid catalyzed one-pot transformation which combined the deprotection of the tert-butylcarbonyl (Boc) group and ring closure reaction together to give a tricyclic nucleobase motif.
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ورودعنوان ژورنال:
- Molecules
دوره 22 4 شماره
صفحات -
تاریخ انتشار 2017