Antibody-Catalyzed Enantioselective Robinson Annulation
نویسندگان
چکیده
We report an antibody that is remarkable in that it catalyzes both steps of an important synthetic transformation, the Robinson annulation. The Robinson annulation which accomplishes, in net terms, the conversion of a f c occupies a key role in organic synthesis.1 In most instances, the overall annulation is comprised of an alkylation (or Michael addition) step leading to b followed by a cyclodehydration step to give a cycloalkenone b f c.
منابع مشابه
Enantioselective synthesis of the ABC ring motif of norzoanthamine based on asymmetric Robinson annulation reactions.
An enantioselective strategy for the synthesis of tetracyclic motif 5, representing the northern fragment of norzoanthamine, is presented. Key to the strategy is the use of two asymmetric Robinson annulation reactions that produce the tricyclic ABC ring system with excellent stereoselectivity. Further functionalization at the periphery of the C ring produces compound 5 containing six contiguous...
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