Vaccines and Autism
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چکیده
The first Wakefield paper In 1998, Andrew Wakefield and colleagues published a paper in The Lancet titled “Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.” Wakefield’s hypothesis was that the MMR vaccine causes a series of events that include intestinal inflammation, loss of intestinal barrier function, entrance into the bloodstream of encephalopathic proteins, and consequent development of autism. In support of his hypothesis, Dr. Wakefield described 12 children with neurodevelopmental delay (8 with autism). All of these children had gastrointestinal complaints and developed autism within 1 month of receiving MMR.
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Autism and thimerosal-containing vaccines: lack of consistent evidence for an association.
BACKGROUND In 1999, concerns were raised that vaccines containing the preservative Thimerosal might increase the risk of autism and/or other neurodevelopmental disorders. METHODS Between the mid-1980s through the late-1990s, we compared the prevalence/incidence of autism in California, Sweden, and Denmark with average exposures to Thimerosal-containing vaccines. Graphic ecologic analyses were...
متن کاملVaccines and autism: evidence does not support a causal association.
A suggested association between certain childhood vaccines and autism has been one of the most contentious vaccine safety controversies in recent years. Despite compelling scientific evidence against a causal association, many parents and parent advocacy groups continue to suspect that vaccines, particularly measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines (TCVs), can caus...
متن کاملThimerosal and the occurrence of autism: negative ecological evidence from Danish population-based data.
OBJECTIVE It has been suggested that thimerosal, a mercury-containing preservative in vaccines, is a risk factor for the development of autism. We examined whether discontinuing the use of thimerosal-containing vaccines in Denmark led to a decrease in the incidence of autism. DESIGN Analysis of data from the Danish Psychiatric Central Research Register recording all psychiatric admissions sin...
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Thimerosal, a mercury-containing preservative used in vaccines, was implicated in 1997 to be linked to autism. Recent in vitro studies suggest that the concentration of thimerosal, and subsequently ethyl mercury, present in vaccines is not cytotoxic. A paucity of studies done specifically with thimerosal has led lawmakers to base regulations on the toxicological profile of methyl mercury. Howev...
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Although child vaccination rates remain high, some parental concern persists that vaccines might cause autism. Three specific hypotheses have been proposed: (1) the combination measles-mumps-rubella vaccine causes autism by damaging the intestinal lining, which allows the entrance of encephalopathic proteins; (2) thimerosal, an ethylmercury-containing preservative in some vaccines, is toxic to ...
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