Cardiac Manifestations of Congenital Generalized Lipodystrophy

نویسندگان

  • Vani P. Sanon
  • Yehuda Handelsman
  • Son V. Pham
  • Robert Chilton
چکیده

IN BRIEF Congenital lipodystrophy is a rare genetic disorder characterized by a near-complete absence of fat cells, hypoleptinemia leading to a voracious appetite, and marked insulin resistance. This article focuses on the known cardiovascular manifestations of patients with congenital lipodystrophy, including cardiomyopathy, cardiac arrhythmias, and accelerated atherosclerosis arising from a markedly deranged metabolic milieu. Future research that targets leptin deficiency (metreleptin) and apoC3 mRNA (antisense oligonucleotide) could open a window for potential pharmacological treatment of this challenging disorder.

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عنوان ژورنال:

دوره 34  شماره 

صفحات  -

تاریخ انتشار 2016