Effect of Photoperiod and Melatonin on Splenocyte Proliferation in Freshwater Snake, Natrix Piscator
نویسندگان
چکیده
The neuroendocrine and immune systems help an organism cope with changing environmental conditions. In recent years, melatonin, a neural hormone synthesized and secreted primarily by the pineal gland (Pelham et al., 1972; Pang and Ralph, 1975), has been suggested to have immunomodulatory roles. The involvement of melatonin in the establishment of a pineal-immune system regulatory axis is currently of interest (Guerrero and Reiter, 1992; Liebmann et al., 1997). In mice, melatonin treatment in vivo increased concanavalin A (Con A)-induced lymphocyte proliferation but decreased lipopolysaccharide (LPS) induced lymphoproliferation (Champney et al., 1997).
منابع مشابه
Daily and Seasonal Rhythms in Immune Responses of Splenocytes in the Freshwater Snake, Natrix piscator
Present study was designed to examine daily and seasonal variability in the innate immune responses of splenocytes in the fresh water snake, Natrix piscator. Animals were mildly anesthetized and spleen was aseptically isolated and processed for macrophage phagocytosis, NBT reduction, nitrite production, splenocyte proliferation and serum lysozyme activity. Samples were collected at seven time p...
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