The biochemical response to biomechanical tissue loading on the low back during physical work exposure.

نویسندگان

  • Gang Yang
  • William S Marras
  • Thomas M Best
چکیده

BACKGROUND Our understanding of low back disorder causality is limited in that how biomechanical loading acting on various spinal tissues initiates the pain pathway is not clear. Previous studies suggest that cytokines may be important in mediating the inflammatory responses in patients with back pain. This study quantified the acute biochemical responses to physical work stressing the low back and assessed the relationships between these systemic responses and specific lumbar spine tissue loads. METHODS Twelve healthy males were tested under control and two weight-lifting conditions (light and heavy). Venous blood was sampled at various time points before and after the physical work and analyzed for cytokine, granulocyte, and creatine kinase levels. Biomechanical data were collected during the tasks and a biologically-assisted lumbar spine model was used to calculate spinal loads at various lumbar spine levels and trunk muscle forces. FINDINGS Levels of interleukin-6, granulocytes, and creatine kinase all increased after both weight-lifting tasks, with the greatest changes observed with the heavier lifting task. Similarly, plasma levels of interleukin-1β and tumor necrosis factor-α both increased following the heavier lifting task. These inflammatory responses were significantly correlated with specific spinal tissue loads. INTERPRETATION This study suggests that it may be possible to use inflammatory cytokines as biomarkers to monitor the physiological responses of the human body to biomechanical loading. Identifying the possible sources of cytokine up-regulation using an advanced biomechanical model may help a more effective understanding of the causal pathways that lead to low back disorders.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Immune responses to low back pain risk factors.

$\underline{Objective}$: Investigate effects of interactions between biomechanical, psychosocial and individual risk factors on the body's immune inflammatory responses. $\underline{Background}$: Current theories for low back pain causation do not fully account for the body's response to tissue loading and tissue trauma. $\underline{Methods}$: Two groups possessing a preference for the sensor o...

متن کامل

The Effect of Thera-Band Resistance Training on the Electromyography Frequency Spectrum of Trunk and Lower Limb Muscles in Low Back Pain Patients with Pronated Feet During Walking: A Clinical Trial

Background and Objectives: Lower back pain is a common orthopedic illness that has a reasonable relationship to pronated foot. The aim of this study was to determine the effects of resistance training with Thera-Band on the electromyography frequency domain of trunk and lower limb muscles of patients with both low back pain and pronated feet during walking. Materials and Methods: This clinical...

متن کامل

A comparison of planatar pressure variables during three differnt running patterns in pronated feet individuals with and without low back pain

 Aims and background: Individuals with pronated feet suffer from many biomechanical dysfunctions during running. The purpose of this study was to compare the peak plantar pressure in ten areas of the foot, ground reaction force, center of pressure and loading rate during three different running patterns between healthy subjects and pronated feet individuals with and without LBP. Materials a...

متن کامل

Comparison lower limb joints stiffness in chronic low back pain patients with healthy people while walking

Introduction: Lower back pain is an orthopedic disease that affects up to 80% of people throughout their lifetime. It seems that the pattern of muscular activity is related to the components of earthquake photography and should be considered when evaluating back pain and its treatment. The aim of this study was to compare the three-dimensional lower limb joints stiffness during loading response...

متن کامل

Biomechanical analysis of blast-induced traumatic brain injury

  Purpose: Blast-induced traumatic brain injury (bTBI) is one of the causes of death or permanent   invalidity which can occur unexpectedly in both military and civilian populations. This study   set out to conduct a combined Eulerian-Lagrangian computational analysis of the interaction   between a single planar blast wave and a human head in order to assess the extent of intracranial   shock w...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical biomechanics

دوره 26 5  شماره 

صفحات  -

تاریخ انتشار 2011