Synthesis Characterization and Antimicrobial Activity of N- ((5-((6-OXIDO-6-(4 Substituted Phenoxy)-4,8-DIHYDRO-1H- [1,3,2] Dioxaphosphepino [5,6-C]Pyrazol-1-YL) Methyl)- 1,3,4-Thiadiazol-2-YL)Carbamoyl) Substituted Benzene Sulfonamides
نویسنده
چکیده
New novel derivatives of N-((5-((6-oxido-6-(4 substituted phenoxy)-4,8-dihydro-1H-[1,3,2] dioxaphosphepino [5,6-c]pyrazol-1-yl) methyl)-1,3,4-thiadiazol-2-yl)carbamoyl) substituted benzene sulfo namides (7a-o as depicted in scheme) were Synthesized by condensation reaction of 4substituted Phenyl phosphorodichloridates (6a-c) and N-((5-((4,5-bis(hydroxymethyl)-1H-pyrazol-1-yi)methyl)1,3,4-thiadiazol2-yl)carbamoyl) substituted benzene sulfonamides (5a-e). synthons (5a-e) were obtained by deprotection of isopropilidine group of N-((5-((6,6-dimethyl-4,8-dihydro-1H-[1,3]dioxepino[5,6-c]pyrazol-1-yl)methyl)-1,3,4thiadiazol-2-yl)carbamoyl) substituted benzene sulfonamides (4a-e).These synthons (4a-e) were obtained by condensation reaction between methyl (cyclopropyl/per fluoro phenyl /4-bromo phenyl/4-nitro phenyl) sulfonyl carbamates (3a-e).and 5-((6,6-dimethyl-4,8-dihydro-1H-[1,3]dioxepino[5,6-C]pyrazol-1-yl)methyl)-1,3,4-thia diazol-2-amine (2).
منابع مشابه
Synthesis, Characterization and Study of Some N-Substituted Aryl-2- ({4-[(Substituted Aryl Carbamoyl) Methyl]-5-(Pyridin-4-yl)-4H-1, 2, 4-Triazol-3-yl} Sulfanyl) Acetamide
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