The Effect of Muscle and Fasciocutaneous Tissue on Angiogenesis in Open Tibial Fracture Healing
نویسنده
چکیده
Introduction: Open fractures of the leg are a reconstructive challenge. Early restoration of the soft tissue envelope has dramatically improved the outcome of these fractures with regard to deep infection and function. However the ideal tissue for covering open fractures remains controversial. Muscle is said to be superior but the mechanism is unclear. A higher blood flow was thought to be the key factor although this has not been established. Angiogenesis is vital for fracture healing. Vascular endothelial growth factor (VEGF) has been shown to be pivotal and other factors such as fibroblast growth factor 2 (FGF-2), insulin-like growth factor (IGF-1), and platelet-derived growth factor (PDGF-BB) have been implicated. We have developed a novel murine open tibial fracture model to compare the vascularity of muscle and fasciocutaneous tissue and investigate their role in angiogenesis during fracture healing.
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