David Fitch

Phenotypic Plasticity: Different Teeth for Different Feasts

A polyphenism in the nematode Pristionchus pacificus involves the development of different feeding structures in response to an environmental cue, providing a genetic model species for investigating ecologically relevant phenotypic plasticity.

Discovery and Preclinical Characterization of GSK1278863 (daprodustat), A Small Molecule Hypoxia Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor for Anemia

Evolution: An Ecological Context for C. elegans

Despite low global diversity among natural populations of Caenorhabditis elegans, neighboring populations can be as genetically distinct as strains from different continents, probably owing to transient bottlenecks and ongoing dispersal as a dauer larva. Selfing predominates in the wild, but rare outcrossing may also play an important role.

Erratum to: From tokenism to meaningful engagement: best practices in patient involvement in an EU project

[This corrects the article DOI: 10.1186/s40900-015-0004-9.].

Generalized Fitch Graphs: Edge-labeled Graphs that are explained by Edge-labeled Trees

Fitch graphs G = (X,E) are di-graphs that are explained by {⊗, 1}-edge-labeled rooted trees with leaf set X: there is an arc xy ∈ E if and only if the unique path in T that connects the least common ancestor lca(x, y) of x and y with y contains at least one edge with label 1. In practice, Fitch graphs represent xenology relations, i.e., pairs of genes x and y for which a horizontal gene transfe...