Structural revisions of natural products by Computer-Assisted Structure Elucidation (CASE) systems.
نویسندگان
چکیده
منابع مشابه
HPLC-SPE-NMR: a productivity tool in natural products research
Natural products provide excellent potential leads for drug development because of their chemical diversity and biological functionality. However, the productivity of discovery of new, pharmacologically active natural products has traditionally been low due to inherent difficulties and costs associated with extract dereplication, i.e., isolation, purification and structure elucidation of indivi...
متن کاملHPLC-SPE-NMR: a productivity tool in natural products research
Natural products provide excellent potential leads for drug development because of their chemical diversity and biological functionality. However, the productivity of discovery of new, pharmacologically active natural products has traditionally been low due to inherent difficulties and costs associated with extract dereplication, i.e., isolation, purification and structure elucidation of indivi...
متن کاملRecent developments in automated structure elucidation of natural products.
Advancements in the field of Computer-Assisted Structure Elucidation (CASE) of Natural Products achieved in the past five years are discussed. This process starts with a dereplication procedure, supported by structure-spectrum databases. Both commercial and free products are available to support the procedure. A number of new programs,as well as advancements in existing ones, are presented. Fin...
متن کاملComputer assisted structure elucidation of natural products using two-dimensional NMR spectroscopy†
The ideal of computer assisted structure elucidation (CASE) is to generate, exhaustively and without redundancy, all possible structures that are consistent with a particular set of spectroscopic data. The aim is to achieve this goal with the minimum amount of human intervention. In natural product drug discovery the major bottleneck has always been structure elucidation, and it is with this in...
متن کاملApplication of the automated structure elucidation system ( CHEMICS ) to the chemistry of natural products
Principles o f the automated structure elucidation system for organic compounds (CHEMICS) and i t s applications t o natural product chemistry are described. I t i s made clear t h a t CHEMICS i s a t the practical level in structure elucidation of natural products through the introduction of 2D-NMR data processing and specific partial structure elucidation functions t o the system. The CHEMICS...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Natural product reports
دوره 27 9 شماره
صفحات -
تاریخ انتشار 2010