Echovirus 1 Endocytosis into Caveosomes Requires Lipid Rafts, Dynamin II, and Signaling Events□V
نویسندگان
چکیده
*Department of Virology, Haartman Institute, University of Helsinki, FIN-00014 Helsinki, Finland; ‡Department of Biological and Environmental Science, University of Jyväskylä, FIN-40351 Jyväskylä, Finland; §Max Planck Institute for Molecular Cell Biology and Genetics, D-01307 Dresden, Germany; Swiss Federal Institute of Technology Zürich (ETH), CH-8093 Zürich, Switzerland; and ¶Department of Virology and MediCity Research Laboratory, University of Turku, FIN-20520 Turku, Finland
منابع مشابه
Echovirus 1 endocytosis into caveosomes requires lipid rafts, dynamin II, and signaling events.
Binding of echovirus 1 (EV1, a nonenveloped RNA virus) to the alpha2beta1 integrin on the cell surface is followed by endocytic internalization of the virus together with the receptor. Here, video-enhanced live microscopy revealed the rapid uptake of fluorescently labeled EV1 into mobile, intracellular structures, positive for green fluorescent protein-tagged caveolin-1. Partial colocalization ...
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Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids that are involved in the lateral compartmentalization of molecules at the cell surface. Internalization of ligands and receptors by these domains occurs via a process defined as raft-dependent endocytosis. Caveolae are caveolin-1-enriched smooth invaginations of the plasma membrane that form a subdomain of li...
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Steady-state surface levels of the apical Na/K/2Cl cotransporter NKCC2 regulate NaCl reabsorption by epithelial cells of the renal thick ascending limb (THAL). We reported that constitutive endocytosis of NKCC2 controls NaCl absorption in native THALs; however, the pathways involved in NKCC2 endocytosis are unknown. We hypothesized that NKCC2 endocytosis at the apical surface depends on dynamin...
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