Uptake of catecholamines by human cardiac muscle in vitro.
نویسندگان
چکیده
Noradrenaline uptake was studied using heart muscle from 102 patients undergoing cardiac surgery. Slices of right atrium were incubated in Krebs-Henseleit solution containing 1.3 x 10(-7) M 3H-noradrenaline. Uptake was lower in failing heart muscle and was inhibited not only by increasing the noradrenaline concentration in the incubating medium but also by adding the drugs desmethylimipramine, amitryptyline, and ouabain.
منابع مشابه
The uptake and binding of six radiolabeled cardiac glycosides by guinea-pig hearts and by isolated sarcoplasmic reticulum.
The Effect of Calcium and Sodium Ion on the Frequency-Force Relationship in Cardiac Muscle. DAVID 0. TEIGER AND ALFRED FARAH 1 The Uptake and Binding of Six Radiolabeled Cardiac Glycosides by Guinea-Pig Hearts and by Isolated Sarcoplasmic Reticulum. S. DUTTA, S. Gosw u, D. K. DATrA, J. 0. LINDOWER AND B. H. MARKS 10 The Effects of Cardiac Glycosides and Their Interaction with Catecholamines on ...
متن کاملβ-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β1 Integrins
Increased sympathetic nerve activity to the myocardium is a central feature in patients with heart failure. Accumulation of catecholamines plays an important role in the pathogenesis of heart disease. Acting via β-adrenergic receptors (β-AR), catecholamines (norepinephrine and isoproterenol) increase cardiac myocyte apoptosis in vitro and in vivo. Specifically, β(1)-AR and β(2)-AR coupled to Gα...
متن کاملRegulation of Cardiac Muscle Contractility
The heart's physiological performance, unlike that of skeletal muscle, is regulated primarily by variations in the contractile force developed by the individual myocardial fibers. In an attempt to identify the basis for the characteristic properties of myocardial contraction, the individual cardiac contractile proteins and their behavior in contractile models in vitro have been examined. The lo...
متن کاملEvaluation of In Vitro Differentiation of Cardiomyocyte-like cells Derived from Human Bone Marrow Mesenchymal Stem Cells
Purpose: To investigate the in vitro differentiation process of cardiomyocyte-like cells derived from human bone marrow mesenchymal stem cells under the influence of 5-azacytidine (5-aza). Materials and Methods: After purification, human bone marrow mesenchymal stem cells were exposed to 5-aza at a concentration of 5 μmol for 5 weeks to induce cardiomyocyte differentiation. To induce differenti...
متن کاملClinical and therapeutic significance of the Na+,K+ pump*.
1. The Na+,K+-ATPase or Na+,K+-pump, mediating the active transport of Na+ and K+, which was first identified 40 years ago, is a central target for acute and long-term regulation, as well as for therapeutic intervention. Acute stimulation of the Na+,K+-pump in skeletal muscle by insulin, catecholamines, beta2-agonists or theophylline increases the intracellular uptake of K+ and accounts for the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British heart journal
دوره 41 3 شماره
صفحات -
تاریخ انتشار 1979