Analog insulin detemir for patients with type 1 and type 2 diabetes: a review
نویسنده
چکیده
OBJECTIVE To review insulin detemir for clinical use to better manage patients with type 1 and type 2 diabetes. METHODS A MEDLINE search, in English, from June 30, 2006 to December 1, 2008, using the terms "insulin analogs," "insulin detemir" and "long-acting insulin analog." RESULTS Insulin detemir improves glycemic control, based on HbA(1C) reduction and fasting glucose levels, without increasing the risk of hypoglycemia and weight gain. Insulin detemir has lower glycemic variability, with less intra-subject variability in blood glucose levels in patients with type 1 and type 2 diabetes, without increasing the risk of hypoglycemia. When added to oral anti-diabetes agents (OADs) in type 2 diabetes, insulin detemir demonstrates superiority to other basal insulin options. CONCLUSION Insulin detemir appears to provide better glycemic control with a lower risk of hypoglycemia and less weight gain in the treatment of patients with type 1 and type 2 diabetes.
منابع مشابه
An update on the treatment of type 1 and type 2 diabetes mellitus: focus on insulin detemir, a long-acting human insulin analog
Basal insulin analogs are used to minimize unpredictable processes of NPH insulin. Modification of the human insulin molecule results in a slower distribution to peripheral target tissues, a longer duration of action with stable concentrations and thus a lower rate of hypoglycemia. Insulin detemir is a basal insulin analog that provides effective therapeutic options for patients with type 1 and...
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PURPOSE To highlight the pharmacology, clinical data, and practical application for the use of insulin detemir, a new long-acting insulin analog in the treatment of type 2 diabetes. DATA SOURCES Published clinical, pharmacokinetic, and pharmacodynamic studies of insulin detemir, as well as contemporary studies and reviews about the management of patients with type 2 diabetes. CONCLUSIONS In...
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BACKGROUND Insulin detemir, a long-acting basal insulin analog, is labeled for once-daily or twice-daily dosing in patients with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus. Protocols for some earlier clinical studies of detemir evaluated twice-daily dosing, which may have generated the misperception that detemir should be prescribed twice daily for most patients. This review examines phar...
متن کاملEvaluation of dosing and clinical outcomes in patients undergoing conversion of insulin glargine to insulin detemir.
STUDY OBJECTIVES To evaluate the dose and frequency of insulin detemir for patients with diabetes mellitus undergoing conversion from insulin glargine to insulin detemir, and to assess glycemic control, weight gain, and risk of hypoglycemia after converting to insulin detemir. DESIGN Retrospective medical record review. SETTING Large academic medical center. PATIENTS Thirty-one patients w...
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