The effects of Alkanna tinctoria Tausch on split-thickness skin graft donor site management: a randomized, blinded placebo-controlled trial
نویسندگان
چکیده
BACKGROUND A prospective, randomized, placebo-controlled clinical trial was conducted to compare the healing effectiveness of Alkanna tinctoria (L.) Tausch (Boraginaceae) with standard dressing on wound healing at the donor site after removal of the skin graft. METHODS Enrolled patients were randomly allocated to receive topicalA. tinctoria extract ointment (20%) or standard dressing (dressing with base ointment) daily. Wound healing was assessed using the Bates-Jenson assessment tool at the 2nd and 4th weeks after intervention. RESULTS Decreases in wound score were significantly greater in the A. tinctoria group compared with the placebo group (P <0.05). The surface areas of graft donor sites in the A. tinctoria group were significantly reduced as compared with the control group at day 28 of the intervention (P < 0.05). The proportion of patients in the A. tinctoria group achieving complete wound healing within 2 to 4 weeks was 50% and 96.66%, respectively, significantly higher than in patients receiving standard care: 0% and 23.3%, respectively. CONCLUSIONS This clinical study showed that A. tinctoria dressing accelerates wound healing after graft harvesting. TRIAL REGISTRATION IRCT ID: IRCT201511165781N2 .
منابع مشابه
Histological evaluation of the anti-inflammatory effects of Alkanna tinctoria on the cutaneous wounds healing in rat
Introduction: Searching the methods improving wound healing is always one of the major subjects of interest. Alkanna tinctoria is applied as a wound dressing since ancient times in traditional medicine, however its healing effects was not evaluated histologically. Methods: 96 male Sprague – Dawley rats were randomly divided into three (experimental, placebo, and control) groups. On the ba...
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