Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer.
نویسندگان
چکیده
منابع مشابه
Investigating the rate of glutathione S-transferase T1 and M1 genes deletion in patients with lung cancer
Introduction: Glutathione S-tarnsferases (GST) gene family is one of the enzymes which is responsible for detoxifying mutagens and Carcinogens chemicals. People with null genotype of GSTM1 and GSTT1 genes are at higher risk of developing cancer, especially those who are related to smoking. The goal of this study was investigating the rate of glutathione S-transferase T1 and M1 genes deletion an...
متن کاملDoes Occupational Exposure to Solvents and Pesticides in Association with Glutathione S-Transferase A1, M1, P1, and T1 Polymorphisms Increase the Risk of Bladder Cancer? The Belgrade Case-Control Study
OBJECTIVE We investigated the role of the glutathione S-transferase A1, M1, P1 and T1 gene polymorphisms and potential effect modification by occupational exposure to different chemicals in Serbian bladder cancer male patients. PATIENTS AND METHODS A hospital-based case-control study of bladder cancer in men comprised 143 histologically confirmed cases and 114 age-matched male controls. Delet...
متن کاملInvestigation of the Relationship between Genetic Polymorphisms in GSTM1 and GSTT1 Genes and Susceptibility to Lung Functional Abnormalities in Workers Exposed to Air Pollutants at Isfahan Steel Plant
Introduction: Gaseous air pollutants can cause oxidative stress, which can lead to lung damage by inducing inflammation. Polymorphisms in the glutathione S-transferase (GST) gene are involved in the pathogenesis of many diseases, including lung disease. Two glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) genes belong to this family, in which deletions occur ...
متن کاملGlutathione S-transferase M1 polymorphism and bladder cancer risk: a meta-analysis involving 33 studies.
Glutathione S-transferase M1 (GSTM1) might be involved in inactivation of procarcinogens that contribute to the genesis and progression of cancers. GSTM1 null status has been extensively studied as a risk factor in bladder cancer susceptibility. The aim of this study is to evaluate the role of GSTM1 null genotype in bladder cancer risk. All available studies were considered in this meta-analysi...
متن کاملPooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review.
Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in tobacco smoke; a homozygous deletion of this gene in approximately 50% of Caucasians and Asians results in a lack of GSTM1 enzyme activity. Most studies examining the relation between bladder cancer...
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ورودعنوان ژورنال:
- BMJ
دوره 307 6902 شماره
صفحات -
تاریخ انتشار 1993