Histological Study of Adrenal Cortical Tumors in Gonadectomized Mice of the ce Strain*t
نویسنده
چکیده
It has recently been reported from this laboratory that carcinoma of the adrenal cortex occurred in a high percentage of cases in extreme dilution strain ce mice that were gonadectomized at 2 days of age (3). The material collected from these animals is especially valuable because it gives a chance to study and detect the very early changes that precede and lead to the formation of rare tumors of this type. Therefore, in this histopathological study special emphasis will be given to the description of these early changes, which are unique in this strain and may justifiably be considered as significant steps leading to tumor formation.
منابع مشابه
The Incidence of Adrenal Cortical Carcinoma in Gonadectomized Female Mice of the Extreme Dilution Strain
Gonadectomized mice of the ce strain are of interest because they have a high incidence of adrenal cortical carcinomas (2). These tumors are extremely rare in normal mice, as evidenced by observations at the Jackson Memorial Laboratory and by the infrequent references to such growths in the literature. Adrenal cortical carcinomas are themselves of special interest because of evidence that they ...
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Neoplasms of the adrenal cortex have appeared following gonadectomy in mice of both sexes of certain strains (2, 3, 10-17), and there were indications that such adenomas secreted estrogenic hormone. Although the incidence of cortical adenomas was high in gonadectomized mice of these strains, similar tumors in noncastrate animals are apparently very rare (1, 8). Consequently, it was of interest ...
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