Single-dose azithromycin microsphere formulation: a novel delivery system for antibiotics

Novel, single-dose microsphere formulation of azithromycin extended-release for the treatment of respiratory tract infections

Biocompatibility research of a novel pH sensitive ion exchange resin microsphere

The main objective of this study was to investigate biocompatibility and provide in vivo pharmacological and toxicological evidence for further investigation of the possibility of pH sensitive ion exchange resin microsphere for clinical utilizations. Acute toxicity study and general pharmacological studies were conducted on the pH sensitive ion exchange resin microsphere we prepared. The genera...

Exploring the potential of complex-vesicle based niosomal ocular system loaded with azithromycin: Development of in situ gel and ex vivo characterization

Abstract Bacterial conjunctivitis characterized as pink eye referred as an inflammation of an eye caused by the enlargement of blood vessels present in conjunctiva, resulting in a red or bloodshot appearance of the eyes. Topical ocular delivery is found to be useful in treating conjunctivitis, but to maintain an effective drug concentration at a site of action in order to achieve desired pha...

Clinical development of 1% azithromycin in DuraSite®, a topical azalide anti-infective for ocular surface therapy

Conjunctivitis, or inflammation of the conjunctiva, refers to a diverse group of ocular surface diseases of viral or bacterial origin that primarily affect the conjunctiva. In developed countries, the most common causative bacterial pathogens are Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pneumoniae. Most varieties of conjunctivitis are self-limiting; however, some cases c...

Biocompatibility research of a novel pH sensitive ion exchange resin microsphere

The main objective of this study was to investigate biocompatibility and provide in vivo pharmacological and toxicological evidence for further investigation of the possibility of pH sensitive ion exchange resin microsphere for clinical utilizations. Acute toxicity study and general pharmacological studies were conducted on the pH sensitive ion exchange resin microsphere we prepared. The genera...