Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese children.

Journal of Hepatology 20 group of heterozygous or homozygous subjects for the major allele (p = 0.02 for ALT and p = 0.01 for steatosis). Moreover, after weight loss, no differences among PNPLA3 genotypes were found in ALT levels or in the prevalence of steatosis (p = 0.1 and p = 0.2, respectively). Both the relationships between DBMI SDS and DALT and between DW/Hr and DALT were analysed, based on the different PNPLA3 genotypes, and the slope of the relative regression lines were compared (Fig. 1). Homozygous children for the PNPLA3 minor allele (148M) showed a stronger correlation between DALT and DW/Hr than those carrying the other genotypes, as we observed in the comparison of regression lines (p = 0.002) (Fig. 1A). The same compar-