A New Modified Protamine Zinc Insulin: Comparison with Histone Zinc Insulin, Clear, and Standard Protamine Zinc Insulins.

A clinical comparison of modified insulins.

The shortcomings of standard protamine zinc insulin when used alone in a single daily injection for the treatment of so-called "severe" diabetes are well known (1-4). Post-prandial glycosuria, nocturnal hypoglycemia, or both, are common and are directly attributed to its slow, gradual but variable rate of absorption from the subcutaneous depot (5). Consequently, increasing attention has been di...

Further Observations on Protamine Zinc Insulin in Clinical Diabetes

One of the main difficulties that the average practitioner encounters regarding the use of msulin in clinical diabetes is the adjustment the proper dosage, on account of insulin having no fixed or standard dosage of its own. The result is that, if proper dosages are not employed, there is either little or no reduction in the blood-sugar level if the dose \s too small, or there is dangerous osci...

Protamine Zinc Insulin

Protamine Zinc Insulin

Insulin analogues.

N Engl J Med 2005;352:174-83. Copyright © 2005 Massachusetts Medical Society. he discovery of insulin more than 80 years ago is considered one of the greatest medical breakthroughs of the 20th century. 1 The first commercial insulin preparations contained numerous impurities and varied in potency from lot to lot by as much as 25 percent. Manufacturing techniques improved rapidly, however, which...