Discovery of Novel Opioid Medications, 147
نویسندگان
چکیده
s. National Institute on Drug Abuse Research Monograph 144. NIH Pub No. 94-3749. Washington, DC: Supt. of Docs., U.S. Govt. Print. Off., 1994. p. 91. Esposito, R.U.; Faulkner, W.; and Kometsky, C. Specific modulation of brain stimulation reward by haloperidol. Pharmacol Biochem Behav 10:937-940, 1979. Esposito, R.U., and Kometsky, C. Morphine lowering of self-stimulation thresholds: Lack of tolerance with long-term administration. Science 195:189-191, 1977. Esposito, R.U.; Perry, W.; and Kometsky, C. Effects of d-amphetamine and naloxone on brain stimulation reward. Psychopharmacology 68:187-191, 1980. Esposito, R.U.; Perry, W.; and Kometsky, C. Chlorpromazine and brainstimulation reward: Potentiation of effects by naloxone. Pharmacol Biochem Behav 15:903-905, 1981. Forrest, W.H.; Brown, B.W.; Brown, C.R.; Defalque, R.; Gold, M.; Gordon, H.E.; James, K.E.; Katz, J.; Mahler, D.L.; Schroff, P.; and Teutsch, G. Dextroamphetamine with morphine for the treatment of postoperative pain. N Engl J Med 296:712-715, 1977. Freud, S. Cocaine Papers. (Byck, R., ed.) Ed. compil. New York: New American Library, 1974. Hubner, C.B.; Bain, G.T.; and Kometsky, C. The combined effects of morphine and d-amphetamine on the threshold for brain stimulation reward. Pharmacol Biochem Behav 28:311-315, 1987. Hubner, C.B., and Kometsky, C. The reinforcing properties of the mixed agonist-antagonist buprenorphine as assessed by brain-stimulation reward. Pharmacol Biochem Behav 30:195-197, 1988. Hubner, C.B., and Kometsky, C. Heroin, 6-acetylmorphine and morphine effects on threshold for rewarding and aversive brain stimulation. J Pharmacol Exp Ther 260:1562-567, 1992.
منابع مشابه
Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension
In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow pathway actively regulate conventional outflow resistance was proposed in the 1990s and systematically pursued, exposing novel cellular and molecular mechanisms of intraocular pressure (IOP) regulation. The critical discovery that pharmacologic manipulation of the cytoskeleton of outflow pathway cells dec...
متن کاملMu opioids and their receptors: evolution of a concept.
Opiates are among the oldest medications available to manage a number of medical problems. Although pain is the current focus, early use initially focused upon the treatment of dysentery. Opium contains high concentrations of both morphine and codeine, along with thebaine, which is used in the synthesis of a number of semisynthetic opioid analgesics. Thus, it is not surprising that new agents w...
متن کاملCo-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses
PURPOSE This study investigated the patterns of opioid co-prescription with benzodiazepine and other concomitant medications among opioid users. Opioid dose in each type of co-prescription was also examined. PATIENTS AND METHODS This cross-sectional study was conducted among opioid users receiving concomitant medications at an outpatient tertiary hospital setting in Malaysia. Opioid prescript...
متن کاملOpioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy
Methadone is widely being used for opioid substitution therapy. However, the administration of methadone to opioid dependent individual is frequently accompanied by withdrawal syndrome and chemical dependency develops. Other than that, it is also difficult to retain patients in the treatment programme making their retention rates are decreasing over time. This article is written to higlights th...
متن کاملRole of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes.
Cannabis extracts and synthetic cannabinoids are still widely considered illegal substances. Preclinical and clinical studies have suggested that they may result useful to treat diverse diseases, including those related with acute or chronic pain. The discovery of cannabinoid receptors, their endogenous ligands, and the machinery for the synthesis, transport, and degradation of these retrograde...
متن کامل