Influence of the Triterpenoid Saponin Quil a on Mixed Monolayers of Phosphatidylcholine and Cholesterol
نویسندگان
چکیده
Immune-stimulating complexes (ISCOMs) are colloidal lipidic structures particularly qualified as potent drug delivery systems for vaccine formulations. Morphologically they feature a unique cage-like structure and form spontaneously in an aqueous pseudoternary system of phospholipid, cholesterol and quillaja saponin A (Quil A). Beside the ISCOM matrices other colloidal structures can be found in this system, mainly elongated or ring-like associates [1,2]. Quil A is the responsible agent determining both the formation of the colloidal structures and the stimulating effect on the immune system. To elucidate the underlying mechanisms of the ISCOM formation, we have focused on the influence of Quil A on the lipids by means of a langmuir blodgett (LB) study. Pure and mixed monolayers of cholesterol and phosphatidylcholine on an aqueous subphase were compared to those on a Quil A containing subphase.
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