DMD #18838 Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice
نویسندگان
چکیده
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260 (M.A.F, H.-K. L, A.-M. Y.). Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (F.J.G.). DMD Fast Forward. Published on November 29, 2007 as doi:10.1124/dmd.107.018838
منابع مشابه
Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.
Analysis of the developmental and sexual expression of cytochrome P450 drug-metabolizing enzymes is impeded by multiple and varied external factors that influence its regulation. In the present study, a CYP2D6/CYP3A4-double transgenic (Tg-CYP2D6/CYP3A4) mouse model was employed to investigate hepatic CYP2D6 and CYP3A4 ontogeny and sexual dimorphism. Both age and sex have considerable effects on...
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