Interspecies comparisons of pharmacokinetics and pharmacodynamics of recombinant human erythropoietin (rHuEPO)
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منابع مشابه
Interspecies comparisons of pharmacokinetics and pharmacodynamics of recombinant human erythropoietin.
Erythropoietin (EPO) has a highly conserved structure among mammals, and thus recombinant human EPO (rHuEPO) has biological activity in various species. This study explores the interspecies relationships of the pharmacokinetics (PK) and pharmacodynamics (PD) of rHuEPO. The PK parameters such as clearance (CL) and volume of distribution (V(ss)) after i.v. doses of rHuEPO were obtained in several...
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