Acoustic rhinometry after nasal provocation test, 6 months interim analysis of alumites study, a randomized, controlled, multicentre phase IV study with house dust mites subcutaneous immunotherapy
نویسندگان
چکیده
Methods In this controlled multicentre phase IV study, HDM adult allergic patients were randomized to receive subcutaneous immunotherapy with a 10 IR/ml depot extract plus symptomatic treatment (group A) or only symptomatic treatment (group B) (2:1). Acoustic rhinometry after nasal provocation test (NPT) was selected to objectively assess the efficacy of this treatment by measuring the nasal volume (NV) and minimum cross-sectional area (MCA). A visual analogic scale (VAS) has been used to subjectively assess the efficacy (0-10 scale, lower is better)NPT consists in 5 determinations at intervals of 15 minutes (basal, diluent, 0.01 IR, 0.1 IR, 1 IR) and one last determination 30 minutes after the last administration. The extract used for the NPT was 100 IR/ml of D. pteronyssinus.
منابع مشابه
Two year follow-up of clinical and inflammation parameters in children monosensitized to mites undergoing subcutaneous and sublingual immunotherapy.
BACKGROUND Both SCIT (subcutaneous immunotherapy) and SLIT (sublingual immunotherapy) have clinical and immunologic efficacy in children with rhinitis and asthma but comparative studies are scarce. OBJECTIVE To investigate the clinical and immunological efficacy of mite-specific SLIT and SCIT in children with rhinitis and asthma. METHOD Thirty children monosensitized to house dust mite were...
متن کاملEvidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial
Background Allergen specific immunotherapy (AIT) in elderly patients is controversial, and there is still little evidence supporting the safety and efficacy of this treatment in this population. The study objective was to evaluate the safety and efficacy of AIT for house dust mite allergens in patients over 65 years of age with allergic rhinitis (AR) and a documented allergy to house dust mites...
متن کاملOptical rhinometry in nasal provocation testing
INTRODUCTION Optical rhinometry (ORM) is a technique that allows for direct continuous measurement of changes in blood flow (optical density) in nasal vessels, at the same time analyzing changes per unit of time in the evaluated variable: intravascular blood flow and oxygen saturation. AIM To assess the extent to which ORM can be used as an objective measure of nasal mucosal edema following a...
متن کاملSpecific nasal provocation test with dermatophagoides pteronyssinus monitored by acoustic rhinometry in children and adolescents with allergic rhinitis and controls
Results Median age was 122 months (108 to 143 months) in controls and 142 months (117 to 156 months) in allergic rhinitis group. At the end of the NPT, the mean V5 fall was 5.7% (-8.7% to 4%) in controls and 22.8% (-24% to -20%) in allergic rhinitis group. None of the 15 controls and 88% (15 of 17 patients) of the allergic rhinitis group had a positive Dp NPT. Considering positive NPTs, 23.5% (...
متن کاملAzelastine hydrochloride and budesonide (nasal sprays): effectiveness combination therapy monitored by acoustic rhinometry and clinical symptom score in the treatment of allergic rhinitis
Methods The study population consisted of 28 patients (9 female and 19 males, aged between 18-32 years) with diagnostic of persistent AR (ARIA consensus). This was a randomized, crossover study. Subjects were randomly assigned to receive either azelastine hydrochloride (140 mcg/nostril) or budesonide (64mcg/nostril) or both drugs. All patients received the three treatments using nasal spray twi...
متن کامل