Spinal Cord GABA Receptors Modulate the Exercise Pressor Reflex in
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چکیده
Spinal Cord GABA Receptors Modulate the Exercise Pressor Reflex in 1 Decerebrate Rats 2 3 Han-Jun Wang, Wei Wang, Kaushik P. Patel, George J. Rozanski, Irving H. Zucker 4 5 Department of Cellular and Integrative Physiology 6 University of Nebraska Medical Center, NE 68198-5850, USA 7 8 Running Title: GABA receptors and Exercise Pressor Reflex 9 10 Address for correspondence: 11 Irving H. Zucker, Ph.D. 12 Department of Cellular and Integrative Physiology 13 University of Nebraska Medical Center 14 Omaha, NE 68198-5850, USA 15 Tel: 1-402-559-7161, Fax: 1-402-559-4438 16 E-mail: [email protected] 17 18 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (May 1, 2013). doi:10.1152/ajpregu.00140.2013
منابع مشابه
Spinal cord GABA receptors modulate the exercise pressor reflex in decerebrate rats.
Neurotransmitters and neuromodulators released by contraction-activated skeletal muscle afferents into the dorsal horn of the spinal cord initiate the central component of the exercise pressor reflex (EPR). Whether γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter within the mammalian central nervous system, is involved in the modulation of the EPR at the level of dorsal horn rema...
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Previously, our laboratory showed that estrogen, topically applied to the spinal cord, attenuated the exercise pressor reflex in female cats (Schmitt PM and Kaufman MP. J Appl Physiol 95: 1418-1424, 2003; 98: 633-639, 2005). The attenuation was gender specific and was in part opioid dependent. Our finding that the mu- and delta-opioid antagonist naloxone was only able to partially restore estro...
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