Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/ mTOR pathway Dong-Mei Zhang1,2,†, Jun-Shan Liu1,2,†, Li-Juan Deng1,2,
نویسندگان
چکیده
1Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China, 2Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China, 3School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China and 4Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510632, China
منابع مشابه
Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway
Arenobufagin, a representative bufadienolide, is the major active component in the traditional Chinese medicine Chan'su. It possesses significant antineoplastic activity in vitro. Although bufadienolide has been found to disrupt the cell cycle, the underlying mechanisms of this disruption are not defined. Here, we reported that arenobufagin blocked the transition from G2 to M phase of cell cycl...
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