Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells.

Supplemental Data Relationships between p63 Binding, DNA Sequence, Transcription Activity, and Biological Function in Human Cells

A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.

The human genome is far smaller than originally estimated, and one explanation is that alternative splicing creates greater proteomic complexity than a simple count of open reading frames would suggest. The p53 homologue p63, for example, is a tetrameric transcription factor implicated in epithelial development and expressed as at least six isoforms with widely differing transactivation potenti...

گروه بندی و بررسی الگوی بیان ژن های خانواده bZIP در ریشه گیاه گوجه فرنگی تحت تنش دمای پایین

Transcription factors (TFs) are master regulators that control gene clusters Plant bZIP (basic region/leucine zipper) transcription factors play crucial roles in biological processes. The Tomato genome sequence contains 73 genes of bZIP transcription factors.  The bZIPs in tomato have never been classified. In this study, 73 genes of bZIP transcription factors were classified in 11 groups by th...

Evaluation of MYB93 and MAD8 Genes in Transgenic and Non-Transgenic Rice

Increasing drought tolerance, especially in rice, which is one of the most important crops in Asia, is necessary. Transcription factors are specific sequence DNA-binding proteins that are capable of activating or suppressing transcription. These proteins regulate gene expression levels by binding to cis regulatory elements in the promoter of target genes to control various biological processes ...

Genome-Wide Mapping Indicates That p73 and p63 Co-Occupy Target Sites and Have Similar DNA-Binding Profiles In Vivo

BACKGROUND The p53 homologs, p63 and p73, share approximately 85% amino acid identity in their DNA-binding domains, but they have distinct biological functions. PRINCIPAL FINDINGS Using chromatin immunoprecipitation and high-resolution tiling arrays covering the human genome, we identify p73 DNA binding sites on a genome-wide level in ME180 human cervical carcinoma cells. Strikingly, the p73 ...