BIOLOGICAL ACTIVITIES OF IMIDAZO [ 2 , 1 - b ] [ 1 , 3 , 4 ] THIADIAZOLE DERIVATIVES : A

1,3,4-Thiadiazole skeleton forms an integral part of various medicinal agents and depicts a vast array of biological activities such as antimicrobial, anti-inflammatory, analgesic, antileishmanial, antitumor, anti-tuberculosis, antileptic, antiviral and other activities. 1,3,4-Thiadiazole moiety has many desirable features which makes them pharmaceutically suitable as it can act as “hydrogen binding domain” and “two electron donor system”. On the other hand imidazole nucleus is one of the most important and wellknown five-membered heterocycle, which is abundant in natural products and responsible for biological activities displayed by vast majority of compounds containing this nucleus. In the recent years, a lot of reports have indicated that the fused imidazo[2,1-b][1,3,4]thiadiazoles emerged out as a new class of compounds possessing wide and interesting biological properties. In the present study we have reviewed the different biological activities of imidazo[2,1-b][1,3,4]thiadiazoles and thus highlighting the importance of this scaffold in medicinal chemistry.