[NM-242] Avoiding Anaphylaxis: Pediatric Cutaneous Mastocytosis and Anesthetic Challenges
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چکیده
Background: Pediatric mastocytosis includes a rare spectrum of diseases characterized by abnormal mast cell infiltration in one or more organs. The cutaneous form (urticaria pigmentosa) is the most frequent pediatric clinical variant.1 Various stimuli may cause mast cell degranulation leading to mediator release. However, there have only been few reports of serious anesthesia-related complications in pediatric populations.2 Dexmedetomidine is a potential mast cell stabilizer that has been shown to block histamine-induced bronchoconstriction.3
منابع مشابه
Pediatric mastocytosis: routine anesthetic management for a complex disease.
BACKGROUND Pediatric mastocytosis consists of a spectrum of clinical variants characterized by increased numbers of resident mast cells in various organ systems. Mast cells are instrumental in mediating anaphylaxis and patients with mastocytosis are at risk to develop provoked and unprovoked episodes of anaphylaxis. METHODS We examined perianesthetic records of patients with pediatric mastocy...
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INTRODUCTION In children, cutaneous mastocytosis (CM) is considered to be a benign disease associated with mast cell mediator-related symptoms. However, systemic mastocytosis (SM) and anaphylaxis may also occur. Since the basal serum tryptase (bsT) level reflects mast cell burden, its determination is recommended in the diagnosis and follow-up. AIM To compare clinical presentation and the cou...
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