Extracellular Crosstalk When GDNF Meets N-CAM
نویسندگان
چکیده
N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway.
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ورودعنوان ژورنال:
- Cell
دوره 113 شماره
صفحات -
تاریخ انتشار 2003