Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation.
نویسندگان
چکیده
The structure of a new pancreatic lipase inhibitor, lipstatin, produced by Streptomyces toxytricini was determined as (2S,3S,5S,7Z,10Z)-5-[(S)-2-formamido-4-methylpentanoyloxy ]-2-hexyl-3- hydroxy-7,10-hexadecadienoic lactone by spectroscopic and chemical methods. Structurally lipstatin is closely related to the known esterase inhibitor esterastin. It contains a N-formyl-L-leucine side chain instead of the N-acetyl-L-asparagine in esterastin.
منابع مشابه
The Role of Linoleic Acid, Palmitic Acid and Leucine in Lipstatin Biosynthesis by Streptomyces Toxytricini
Department of Botany & Microbiology, Gurukul Kangri University Haridwar 249404, Uttarakhand, India ABSTRACT: Lipstatin, a new and very potent inhibitor of pancreatic lipase, was isolated from the Streptomyces toxytricini. Lipstatin contain a beta lactone structure that probably account for the irreversible lipase inhibition. As per the biosynthetic pathway the role of linoleic acid, palmitic ac...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 40 8 شماره
صفحات -
تاریخ انتشار 1987