Erythrokinetics in pernicious anemia.

نویسندگان

  • D H COLEMAN
  • D M DONOHUE
  • C A FINCH
  • A G MOTULSKY
  • R H REIFF
چکیده

T HE climmical emitity, permmicious anenmia, is the result. of a prolousged deficiency jut vitamimm 1312. While there is a gemmeral abnornmality throughout the body ins cellular growth ammd immetabolismmm,’ the effects of the deficiemmcy are readily denmoumstrated by the nmegaloblast.ic changes of the erythron. The mmmaummmer iui ivhich ammemia is produced seems imicreasingly complex as nmore detailed hematologic studies have beemm perfornmed. Either the decreased red cell productiomi or the imicreased destruction w’ould seeni to provide adequate explaumation for the anmenmia.24 JIm previous studies, we have attempted to define niore cleam.ly the limits of red cell production immvarious types of ammeummia.5 These studies are exteimded in this article to describe ium detail the quammtit.ative aspects of red cell productionm imi perumicious aumemia imi relapse amid durirmg respommse to B12. These studies mdicat.e that imm pernicious anemia the attempt by the marrow to produce viable red cells is largely ineffective.

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عنوان ژورنال:
  • Blood

دوره 11 9  شماره 

صفحات  -

تاریخ انتشار 1956