Enhancing effect of corticotrophin on thyrotrophin produced exophthalmos in fish.

Goldfish (Carassius auratus, var. japonicus, subvar. bicaudatus) respond to the administration of thyrotrophic hormone with exophthalmos. Eye protrusion increases with simultaneous injections of corticotrophin. Retrobulbar injections of normal saline, human serum or pituitary hormones produce a transient exophthalmos, which is much more persistent when thyrotrophin is injected. Previous treatment of fishes with longacting corticotrophin prolonged the duration of the exophthalmos caused by retrobulbar injections of thyrotrophin; this effect is not observed when other fluids are injected.