Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1â•’ETO mouse model
نویسندگان
چکیده
(1) Medical Center of the Johannes Gutenberg-Universit of Internal Medicine III, Division of Translationa Oncology, Mainz, Germany (2) German Cancer Research Center, Department of Ste Heidelberg, Germany (3) Medical Center of the Johannes Gutenberg-Universit Toxicology, Mainz, Germany (4) German Cancer Research CenterDivision of Mol Heidelberg, Germany (5) TRON – Translational Oncology at the Johannes G Mainz, Mainz, Germany (6) University of Lausanne, Institut Universitaire de Lausanne, Switzerland (7) Medical Center of the Johannes Gutenberg-Universit of Pathology, Mainz, Germany (8) Johannes Gutenberg-University Mainz, Institute for Germany
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Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model
The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pattern of human t(8;21) CBF AML with global transcriptome sequencing, we find that disease progres...
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