The appearance of isometamidium resistant Trypanosoma congolense in West Africa.
نویسندگان
چکیده
The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium prophylaxis in the Upper Volta indicated that drug-resistant forms might be appearing. To investigate this possibility, trypanosome stocks were isolated in mice, their isometamidium sensitivity estimated and compared to that of stocks isolated before drug use was widespread. Most T. congolense stocks isolated in 1982-1983 were 4-8 times less sensitive to isometamidium than those isolated in 1979-1980.
منابع مشابه
Cross-resistance associated with development of resistance to isometamidium in a clone of Trypanosoma congolense.
Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectively. Both T. congolense IL 1180 and the resistant derivative were able to undergo cyclical development...
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Isometamidium chloride (Samorin) is the only compound recommended for prophylaxis against bovine trypanosomiasis in sub-Saharan Africa. The fluorescence property of this compound was used to investigate the interaction of the molecule with in vitro-derived bloodstream forms of Trypanosoma congolense IL 1180. Incubation of isometamidium with trypanosomes at 37 degrees C for 180 min resulted in a...
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BACKGROUND Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever. The existing compounds have become virtually useless and pharmaceutical companies are not keen on investing in the development of new trypanocides. We may have found a breakthrough in the treatment of r...
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Twenty-nine cattle, naturally infected with Trypanosoma congolense Kibaha, were subjected to chemotherapy with diminazene aceturate (Berenil, Hoechst) at 3.5 to 14.0 mg/kg. Fourteen animals recovered while six were refractory to treatment at 7.0 to 14.0 mg/kg. Further treatment of the Berenil-resistant isolates with isometamidium chloride (Samorin, May and Baker) at 1.0 mg/kg, effected cure. Co...
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ورودعنوان ژورنال:
- Acta tropica
دوره 41 3 شماره
صفحات -
تاریخ انتشار 1984