Alkynylation of steroids via Pd-free Sonogashira coupling.

نویسندگان

  • Yury N Kotovshchikov
  • Gennadij V Latyshev
  • Nikolay V Lukashev
  • Irina P Beletskaya
چکیده

Cu-catalyzed Pd-free Sonogashira coupling has been proposed as a straightforward and convenient route to valuable steroidal enynes. A biligand catalyst system based on Ph3P and TMEDA has been designed. The protocol was utilized for the efficient coupling of iodosteroids with diverse terminal alkynes and 1-trimethylsilylalkynes. A possible role of an auxiliary ligand as a phase-transfer catalyst for a sparingly soluble inorganic base (K2CO3) was revealed.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 13 19  شماره 

صفحات  -

تاریخ انتشار 2015