Highly reduced analogues of the pyridine nucleotide coenzymes. Synthesis of tetrahydro- and hexahydronicotinamide adenine dinucleotides and certain of their derivatives.

Catalytic hydrogenation of the appropriate pyridine nucleotide coenzymes and their derivatives over palladium supported on barium carbonate in aqueous solution has yielded the following representatives of two novel series of coenzyme analogues: tetrahydronicotinamide adenine dinucleotide, tetrahydronicotinamide mononucleotide, 3-acetyltetrahydropyridine adenine dinucleotide, hexahydronicotinamide adenine dinucleotide, and hexahydronicotinamide adenine dinucleotide phosphate.