Effects of Inorganic Mercury on Osteoclasts and Osteoblasts of the Goldfish Scales In Vitro
نویسندگان
چکیده
Heavy metals such as mercury, cadmium and copper are known to be extremely toxic to organisms. Mercury has been recognized as an environmental contaminant since the Minamata disaster in the late 1950s. Minamata disease which was caused by the consumption of marine fishes severely polluted with mercury from local industrial discharge due to this Minamata disaster (Takeuchi et al., 1978; Takeuchi, 1982). This extremely adverse situation occurred because of mercury, a highly toxic compound, was severely bio–accumulated (in case of long– finned eels: approx. 1,000,000 times higher than environmental water) by fish (Redmayne et al., 2000). The effect of mercury on the central nervous system has widely studied and revealed that mercury is a neuro– toxic material, and its poisoning effect is characterized by the damage in discrete portions of the brain, such as the visual cortex and the granule layer of the cerebellum (Castoldi et al., 2001). As bio–accumulation of mercury in bone is lower than that in neural tissues (Boyer et al., 1978; Doyle, 1979; Berglund et al., 2000), much attention has not been given to bone in this area of research. Recently, Lake et al. (2006) reported that the correEffects of Inorganic Mercury on Osteoclasts and Osteoblasts of the Goldfish Scales In Vitro
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