17-P021 Nanog-dependent segregation of germ line and soma in axolotl animal caps by patterning signals: Induction of primordial germ cells (PGCs) by FGF

mordial germ cells (PGCs) in mice and axolotls, we propose that the deletion of Nanog in species often employed as experimental models, such as frogs and teleosts (Zebrafish; Danio rerio), has been compensated by the evolution of predetermined germ cells in these organisms. Our data highlights Nanog as a major component of the gene regulatory network that governs early development in the major trunk of chordate evolution.