Stem Cell Reports Article Castration-Resistant Lgr5 Cells Are Long-Lived Stem Cells Required for Prostatic Regeneration
نویسندگان
چکیده
Bu-er Wang,1 Xi Wang,1 Jason E. Long,1 Jeff Eastham-Anderson,2 Ron Firestein,3 and Melissa R. Junttila1,* 1Department of Translational Oncology 2Center for Advanced Light Microscopy 3Department of Pathology Genentech, 1 DNAWay, South San Francisco, CA 94080, USA *Correspondence: [email protected] http://dx.doi.org/10.1016/j.stemcr.2015.04.003 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Castration-Resistant Lgr5+ Cells Are Long-Lived Stem Cells Required for Prostatic Regeneration
The adult prostate possesses a significant regenerative capacity that is of great interest for understanding adult stem cell biology. We demonstrate that leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) is expressed in a rare population of prostate epithelial progenitor cells, and a castration-resistant Lgr5(+) population exists in regressed prostate tissue. Genetic lineage tr...
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