Synthesis of heterocycles via palladium-catalyzed oxidative addition.

Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.

Synthesis of Saturated Five-Membered Nitrogen Heterocycles via Pd-Catalyzed C N Bond-Forming Reactions

Saturated five-membered nitrogen heterocycles, such as pyrrolidines, indolines, and isoxazolidines, appear as subunits in a broad array of biologically active and medicinally significant molecules [1]. As such, the synthesis of these compounds has been of longstanding interest. Many classical approaches to the construction of these heterocycles involve the use of C N bond-forming reactions such...

Palladium-Catalyzed Oxidative Acyloxylation/Carbocyclization of Allenynes**

Palladium(II)-catalyzed oxidative carbocyclizations represent an important class of reactions, which have provided powerful and atom-economical approaches to carboand heterocycles. In particular, oxidative carbocyclization strategies have been efficiently applied to total synthesis. As a continuation of our research on the palladium-catalyzed oxidative carbocyclizations of dienallenes and enall...

Regioselective palladium-catalyzed intramolecular oxidative aminofluorination of unactivated alkenes.

A novel Pd-catalyzed regioselective intramolecular aminofluorination of unactivated alkenes has been developed, which is an efficient method for the synthesis of a variety of monofluoromethylated nitrogen-containing heterocycles.

Synthesis of heterocycles via palladium-catalyzed carbonylations.