NKX 2 - 2 ( NK 2 homeobox 2 )
نویسندگان
چکیده
273 amino acids; 30133 Da. NKX2-2 is a member of the NK2 family of homeobox transcription factors. It has known roles in the development of the CNS as well as pancreatic beta cell differentiation. In the CNS NKX2-2 is known to be activated by SHH signaling which is important for its initial role in ventral patterning. NKX2-2 expression has additionally been shown to be critical for the differentiation of oligodendrocytes, and in fact necessary for this process to occur. In both instances, NKX2-2 mediated transcripitional repression is both necessary and sufficient for these processes to occur. Regulation of NKX2-2 expression in the pancreas is less well understood. NKX2-2 knock-out mice die soon after birth from diabetic complications as a result of a lack of fully differentiated pancreatic beta cells. While NKX22 mediated transcriptional repression has been demonstrated to be necessary and sufficient for its role in beta-cell differentiation, it remains unclear whether NKX2-2 mediated transcriptional activation is important for NKX2-2 function in adult beta-cells.
منابع مشابه
A novel leech homeobox gene, Lox10, is shown to encode a homeodomain sequence characteristic of a phyletically widespread NK-2 homeobox gene
Homeobox genes have been implicated in a number of regulatory processes associated with the embryonic patterning and cell differentiation of eukaryotes (McGinnis and Krumlauf, 1992). The homeobox is a 180 bp DNA sequence which encodes a 60 amino acid protein motif, the homeodomain, that has been shown to serve as the DNA binding site for a phyletically and functionally diverse class of transcri...
متن کاملA novel leech homeobox gene, Lox10, is shown to encode a homeodomain sequence characteristic of a phyletically
Homeobox genes have been implicated in a number of regulatory processes associated with the embryonic patterning and cell differentiation of eukaryotes (McGinnis and Krumlauf, 1992). The homeobox is a 180 bp DNA sequence which encodes a 60 amino acid protein motif, the homeodomain, that has been shown to serve as the DNA binding site for a phyletically and functionally diverse class of transcri...
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