CALL FOR PAPERS Cardiovascular and Cerebrovascular Aging—New Mechanisms and Insights Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats
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چکیده
Anna Csiszar, Tripti Gautam, Danuta Sosnowska, Stefano Tarantini, Eszter Banki, Zsuzsanna Tucsek, Peter Toth, Gyorgy Losonczy, Akos Koller, Dora Reglodi, Cory B. Giles, Jonathan D. Wren, William E. Sonntag, and Zoltan Ungvari Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Pathophysiology and Gerontology, Medical School and Szentagothai Research Center University of Pecs, Pecs, Hungary; Department of Anatomy, MTA-PTE Lendulet Research Group, Medical School, University of Pecs, Pecs, Hungary; Department of Pulmonology, Semmelweis University, Budapest, Hungary; Oklahoma Medical Research Foundation, Arthritis and Clinical Immunology Research Program and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma
منابع مشابه
Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
Age-related impairment of angiogenesis is likely to play a central role in cerebromicrovascular rarefaction and development of vascular cognitive impairment, but the underlying mechanisms remain elusive. To test the hypothesis that dysregulation of Dicer1 (ribonuclease III, a key enzyme of the microRNA [miRNA] machinery) impairs endothelial angiogenic capacity in aging, primary cerebromicrovasc...
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Objective(s): Fluvoxamine is a well-known selective serotonin reuptake inhibitor (SSRI); Despite its anti-inflammatory effect, little is known about the precise mechanisms involved. In our previous work, we found that IP administration of fluvoxamine produced a noticeable anti-inflammatory effect in carrageenan-induced paw edema in rats. In this study, we aimed to evaluate the effect of fluvoxa...
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Cardiovascular diseases are a major cause of death worldwide. Endothelial dysfunction, inflammatory conditions, and oxidative stress at the forefront of the onset and progression of most cardiovascular diseases specificaly coronary heart disease and heart failure. Melatonin is a type of indole neuroendocrine hormone. It was first found that the regulation of the sleep-wake cycle is regulated...
متن کاملActivation-Induced Apoptosis in T cells: Effect of Age and Caloric Restriction
We have previously shown that the proliferative response of T cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (CR) attenuated the age-related decline in proliferation and IL-2 expression. Because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...
متن کاملProtective Effect of Pomegranate Seed Oil against D-Galactose-Induced Aging in Rats
Background and Objective: Aging is a natural phenomenon which can cause changes in most organs and cells. Numerous mechanisms including oxidative stress and free radical generation is involved in the progression of the aging process. Pomegranate seed oil (PSO), has different therapeutic properties including anti-oxidant and anti-inflammatory effects. In this research, the effect of PSO against ...
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تاریخ انتشار 2014