Testosterone-induced neuronal apoptosis ELEVATED TESTOSTERONE INDUCES APOPTOSIS IN NEURONAL CELLS
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چکیده
ELEVATED TESTOSTERONE INDUCES APOPTOSIS IN NEURONAL CELLS Manuel Estrada*#, Anurag Varshney* and Barbara E. Ehrlich† Departments of Pharmacology and Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA Running title: Testosterone-induced neuronal apoptosis * These authors contributed equally to this work and are listed alphabetically. †Corresponding author: Barbara E Ehrlich, Department of Pharmacology, Yale University, 333 Cedar Street, New Haven, CT 06520-8066. Phone 203 737 1158; Fax 203 737 2027; E-mail: [email protected]. # Present address: Programa de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Correo 7, Santiago, Chile. Phone 56 2 9786272, Fax 56 2 7776916 Email: [email protected]
منابع مشابه
Elevated testosterone induces apoptosis in neuronal cells.
Testosterone plays a crucial role in neuronal function, but elevated concentrations can have deleterious effects. Here we show that supraphysiological levels of testosterone (micromolar range) initiate the apoptotic cascade. We used three criteria, annexin V labeling, caspase activity, and DNA fragmentation, to determine that apoptotic pathways were activated by testosterone. Micromolar, but no...
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